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The Bench to Bassinet Program is a major effort launched by the National Heart,
Lung, and Blood Institute to learn more about how the heart develops and why children
are born with heart problems. This information will be used to develop new ways to
help infants, children, teenagers, and adults born with heart disease.
OUR MISSION: The Bench to Bassinet's mission is to accelerate
scientific discovery to clinical practice by fostering collaborations of basic,
translational and clinical researchers through a flexible program designed to improve
outcomes for individuals with congenital heart disease while supporting the needs
of the pediatric heart disease research community.
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CHD GENES
The Pediatric Cardiac Genomics Consortium launches its prospective cohort study
Subjects Enrolled: 3,633
Relatives Enrolled: 4,485 |
Learn more
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BBC
NEWS HEALTH highlights discovery by CvDC Centers
Delgado-Olguín et al have discovered a previously unknown mechanism
that finely regulates cardiac growth and stress-responsiveness. They show
that cardiac homeostasis is maintained epigenetically by a protein called
Ezh2, by shutting off another gene, Six1, which otherwise would activate
skeletal muscle genes and cause cardiac pathology. These results suggest
that epigenetic errors occurring in embryonic progenitor cells during
gestation predispose adults to cardiac disease. Read the complete article at
BBC
NEWS HEALTH.
See
Epigenetic
repression of cardiac progenitor gene expression by Ezh2 is required for
postnatal cardiac homeostasis for more information.
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CvDC Datasets
Several datasets are now publicly available. Information can be found on the
DataSets page under the For Researchers
tab. Information about novel mutant lines can be found on the
Reagents page.
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