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Bench To Bassinet Program logo

The Bench to Bassinet Program is a major effort launched by the National Heart, Lung, and Blood Institute to learn more about how the heart develops and why children are born with heart problems. This information will be used to develop new ways to help infants, children, teenagers, and adults born with heart disease.

OUR MISSION: The Bench to Bassinet's mission is to accelerate scientific discovery to clinical practice by fostering collaborations of basic, translational and clinical researchers through a flexible program designed to improve outcomes for individuals with congenital heart disease while supporting the needs of the pediatric heart disease research community.

CHD GENES

The Pediatric Cardiac Genomics Consortium launches its prospective cohort study
Subjects Enrolled: 3,633
Relatives Enrolled: 4,485
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BBC NEWS HEALTH highlights discovery by CvDC Centers

Delgado-Olguín et al have discovered a previously unknown mechanism that finely regulates cardiac growth and stress-responsiveness. They show that cardiac homeostasis is maintained epigenetically by a protein called Ezh2, by shutting off another gene, Six1, which otherwise would activate skeletal muscle genes and cause cardiac pathology. These results suggest that epigenetic errors occurring in embryonic progenitor cells during gestation predispose adults to cardiac disease. Read the complete article at BBC NEWS HEALTH.

See Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis for more information.


CvDC Datasets

Several datasets are now publicly available. Information can be found on the DataSets page under the For Researchers tab. Information about novel mutant lines can be found on the Reagents page.